The Instrumentation Group has long been a part of IIT Delhi's Centre for Biomedical Engineering. The group's mission is to promote cutting-edge biomedical engineering research and development. The group is unique in the field of Biomedical Engineering in that it offers graduate training and research experience in a variety of fields. At present, the Group consists of three professors with a wide range of research interests who are investigating the following thrust areas: • Neuromechanics By integrating computational biomechanics approaches with neural data to discover the underlying neural mechanism of gait equilibrium in healthy and clinical populations, the groups investigate the recovery and advancement of assistive devices for clinical populations such as an amputee, cerebral palsy, epilepsy, stroke and spinal cord injured patients. Furthermore, the group studies the neural characterization of balance and gait in various neurodegenerative diseases. • Lab-on-a-chip and Biosensors Where the groups look at non-invasive clinical biosensors, capillary electrophoresis microchip devices for clinical, environmental, and biopharmaceutical applications, microfluidic Lab-on-a-chip for PCR, and on-chip cytometry, on-chip COD analysis, pathogen detection biosensors, and an on-chip neurochemical analyzer. • Biomechatronics and imaging The group focuses on the development of complex biomechatronic and biomedical systems that incorporate diverse sensing paradigms, electronics, ultrasound imaging, signal processing, embedded hardware, and software to better understand human movement, neuromuscular disorders, and chronic disability in general.
Biomaterials group integrated the concepts and skills from chemistry, materials science, and biology to design, synthesize, characterize, evaluate, and validate next-generation biomaterials to make a translational impact on improving human health. We work in the domain of nano-structured materials to improve their functionality for applications in biomedical implants, cancer diagnostics, and drug delivery. Our research interest is the development of bio-inspired and bio-derived materials to meet unmet needs in treating and diagnosing disease. Some of our research areas are: - • Cancer Immunotherapy. • Smart Functional Nanomaterials (drug delivery, biosensors and biomedical implant coatings). • Tissue Engineering. • Biomaterials and Bioengineering: new functionalized and bioactive polymeric materials. • Non-invasive clinical biosensors. • Biosensors for pathogen detection.
In collaboration with IIT-Delhi and AIIMS-Delhi, the Biomechanics group is a team of multi-disciplinary researchers with expertise in diagnostics, experiments and testing, design and simulation of biological systems, and healthcare products development. We focused on designing medical devices, validating their performance clinically, and developing associated manufacturing processes. We develop both diagnostic devices as well as implantable devices. Our group also works on tissue biomechanics and developing musculoskeletal models. The aim of this group is to understand the biomechanics of the human body through simulation and experiments. We also work with individuals with motor disorders for designing sensing systems to detect residual muscle activity which would help to control sophisticated prosthetic and orthotic devices. Several projects are currently underway which range from computational modeling of bones/tissues to devices that help human physiology.
In association with IIT-Delhi and AIIMS-Delhi, the Medical Imaging group is working towards developing new analysis and post-processing methodologies for quantitative biomedical imaging that could be beneficial to the much wider clinical community. The group is actively working on the applications of Machine Learning in Healthcare for diagnosis, grading, and treatment monitoring of diseases such as Cancer/tumor, Osteoarthritis, etc. The other research areas of the Medical Imaging group are: Development of quantitative methods, techniques, and software tools in the field of MRI, particularly in, Perfusion-MRI, CEST-MRI, Susceptibility-Weighted-Imaging (SWI), Diffusion-weighted MRI. The medical imaging group also works in Medical Image Processing for the segmentation and classification of tissues, image registration, and mitigation of noise and artifacts.
Medical Implants research group works for the development of indigenous medical devices to serve the Indian population. It focuses on developing affordable solutions for healthcare through a synergy of cutting-edge engineering and medicine. • Dental Implants: Designed from scratch, tested, and evolved in a period of 11 years supported by NMITLI, CSIR is the first dental implant system under the true spirit of “Make in India”. • Hip Protection Device: It is meant to prevent fracture of the hip joint due to a fall of an elderly above the age of 70 due to reduced bone density, Alzheimer, in balance in walking or geriatric problems. • Orthotic Knees Joint: Made by injection molding of selected polymer composites for mass production as low-cost solution with light weight as an offset and gravity drop lock for polio patients. Sponsored by the vision of Sir APJ Kalam and sponsored by DRDO. • Prosthetic Polycentric Knee Joint: Replacing metallic joints with mass produced injection molded knee joint for the above knee amputees. Initially single axis and then polycentric were designed and developed to perform with better gait and stability. • Bioresorbable Cardiac Stent: Fourth generation of CAD treatment, drug eluting and treating BVS is absorbed in the body within 1-2 years and do not require lifelong anti platelet medicines due to positive lumen modeling. Its designed and developed for the IMPRINT project in collaboration with AIIMS cardiology and sponsored by ICMR. • Breast Cancer Tumor Marker: Evolved to preserve breasts from mastectomy suffering from cancer tumor by adjuvant chemotherapy used to dissolve the tumor before surgery. During surgery minimally invasive procedure is devised due to titanium marker developed with nano tubes deployed during FNAC with a small 18 gage needle, no artifacts during imaging and therefore it guides the surgeon to preserve breast.